Aktivitas Anti-inflamasi Ekstrak Etanol Daun Beluntas (Pluchea indica L.) pada Model Inflamasi Terinduksi CFA (Complete Freund's Adjuvant)
Abstract: A research about
anti-inflammatory effect of Beluntas leaves extract on CFA (Complete Freund’s
Adjuvant) induced inflammatory model has been conducted. The objective of this
research was to determine the effect of Beluntas leaves extract in alleviating
CFA-induced paw edema in mice (Mus musculus). The number of mice used was 15
and was divided into 5 groups. Group I was treated with NaCMC. Group II, III,
and IV were given suspension of Beluntas leaves extract 100 mg/Kg, 300 mg/Kg,
and 500 mg/Kg BW, respectively. Group V was a positive control treated with
suspension of diclofenac sodium 0.1 ml/10 g orally. The determination of
anti-inflammatory potency was based on the average time needed to ameliorate
the edema volume. The shortest time
period of edema reduction was produced by diclofenac sodium (within 9.33 days),
then followed by Beluntas leaves extract with the concentration of 300 mg/Kg
(within 12 days), 500 mg/Kg (within 14.33 days), and 100 mg/Kg (within 17.67
days), consecutively. These results are significantly different compared to
negative control group which did not reduce the edema volume during 18 days of
observation. In conclusion, ethanol extract of Beluntas leaves has an effective
anti-inflamatory effect.
Keywords: Anti-inflammatory,
Beluntas Leaves, Pluchea indica, CFA
Penulis: Reza Setiawan
Sudirman, Usmar Usmar, Abdul Rahim, Muh. Akbar Bahar
Kode Jurnal: jpfarmasidd170580
