UBI JALAR UNGU MEMPERBAIKI KADAR SUPEROXIDE DISMUTASE DAN JUMLAH FOAM CELL TIKUS YANG DIPAPAR ASAP ROKOK
Abstrak: Cigarette smoke is a
source of free radicals contains carcinogenic chemical substances.The purple
sweet potatoes contains anthocyanins which has potential antioxidant activities
to neutralize free radicals. This research aim was to know the effect of purple
sweet potatoes extract on the levels of lung’s superoxide dismutase (SOD) and
number of foam cells in aorta of wistar rat which were exposed to cigarette
smoke. This research was an experimental study with complete random design and
post test only control group design. The twenty five wistar divided into five
groups: control group (P0); group was only exposed to cigarette smoke (P1);
groups were exposed to cigarette smoke and purple sweet potatoes extract in
dose of 0,065 (P2), 0,13 (P3), and 0,26 (P4) g/day for 90 days. Data was
analyzed by One Way Anova and Post Hoc Tukey HSD test. The result of this study
indicate that the levels of lung’s SOD were 25,26 ± 2,35; 13,11 ± 3,85; 19,24 ±
3,95; 9,20 ± 6,23; 24,53 ± 5,75 unit/mg, while the average number of foam cells
in aorta were 19,68 ± 7,74; 40,40 ± 10,67; 27,16 ± 4,28; 25,92 ± 5,24; 16,80 ±
4,22 for P1, P2, P3, P4, and P5 respectively. There was different SOD levels in
lung and foam cells in aorta significantly between control and treatment groups
(p < 0,05). It was concluded that the purple sweet potatoes extract can increase
SOD levels in lung and decrease foam cell in aorta of wistar rat which were
exposed to cigarette smoke.
Keywords: purple sweet
potatoes, SOD, foam cell, cigarette smoke
Penulis: Ayuningtyas Dian
Ariestiningsih, Anita Nihlawati, Feti Noor Handayani
Kode Jurnal: jpkesmasdd180086
