The safety evaluation of ethanol extract of torbangun leaves (Coleus amboinicus Lour.) on mouse fetal development
Abstract: The purpose of this
study was to evaluate the safety of ethanol extract from torbangun leaves on
mouse fetal development. This research used 24 female pregnant mouse. The
leaves extract was administered orally at dose level of 0; 0.56; 1.68 and 3.36
g/kg body weight. The extract was given from the first day until the eighteenth
day of pregnancy period. The ethanol extract of Torbangun leaves contains
flavonoids, saponins, tannins, and steroids. The result showed that consumption
of 3.36 g/kg torbangun leaves extract had led to significant differences in the
decrease of maternal weight change, number of live fetuses, fetal weight, and
fetal length. Consumption of Torbangun leaves extract during pregnancy should
be avoided due to its potency to interfere the fetal development.
Keywords: ethanol extract;
pregnancy; teratogenicity; Torbangun
Author: Elma Alfiah, Muhammad
Rizal Martua Damanik, Katrin Roosita, Mokhamad Fahrudin
Journal Code: jpkesmasgg180021
