THE EFFECTIVENESS OF MANGOSTEEN PEELS EXTRACT AGAINST THE TOTAL OF T LYMPHOCYTES IN HIV PATIENTS
ABSTRACT: The Province of West
Java is one of the highest HIV sufferers in Indonesia that has increased
accumulatively in 2013 to 2014. This condition was proven that in 2014 West
Java ranked 4th among the provinces with the highest HIV sufferers in
Indonesia. HIV has main target to infect a cell that contains of receptor, CD4.
CD4 examination routinely is very important to decide HIV replication process.
Meanwhile, CD4 test in the laboratory is quite expensive and not always
available in every health facilities. Mangosteen peels extract contains of
xanthones as an antioxidant, which is needed for body as a prooxidant that can
inhibit the replication of HIV and the activity was seen from the total number
of lymphocyte. Method: The human experimental
research has been done by Randomized Control Group Pretest-Post Test Design.
There were 20 patients sample for each group. In group 1, HIV patients with ARV
therapy were given mangosteen peels extract and in group 2, they were given
placebo capsule. Wilcoxon Smith test and Mann Whitney U test were used to
determine the difference between group 1 and group 2. Result: There is no
significant difference between lymphocytes (p: 0.102) to HIV patients with ARV
in each group examination. Discussion: The ineffectiveness is caused by the
phagocytocity and cytoxity of TNF through the increasing of free radicals in
HIV patients.
KEYWORDS: Mangosteen peels
extract, lymphocytes
Author: Maria Dyah Kurniasari,
Edi Dharmana, Hussein Gasem
Journal Code: jpkesmasgg170019
