Teh putih (Camellia sinensis) dan kelor (Moringa oleifera) sebagai antihiperglikemia pada tikus Sprague dawley yang diinduksi streptozotocin
Abstract: This study aims to
examine the antihyperglycemic effect of white tea (Camellia sinensis) and
Moringa oleifera when administered as a single component and as mixture in
streptozotocin-induced diabetic rats. The study design was experimental. The
first step was to analyze epigallocathecingallat (EGCG) content as standard
with High Performance Liquid Chromatography (HPLC) method. The second step was
intervention in Sprague dawley rats induced by streptozotocin 40 mg/kgBW.
Intervention held for 21 days with given white tea (WT), M. oleifera (MO),
mixture of white tea and M. oleifera (WT+MO) and green tea (GT) as positive
control with reference dose 100 mg/kgBW EGCG. Rats blood glucose and body
weight were measured. The results are WT having the highest content of EGCG
(4.46%). MO and WT+MO only have 2.42% and 2.46% of EGCG while GT as control is
the lowest (1.29%). Measurements of blood glucose and body weight in group that
given WT or MO as single component showed no significant difference with
control negative group (p>0.05). Blood glucose decreased significantly in
group WT+MO (p<0.05). Administration of WT+MO was able to maintain a stable
body weight during the intervention period (p>0.05). The combination of
white tea and M. oleifera has better ability as an antihiperglycemic agent
compared to single component.
Keywords: antihiperglycemic;
Camellia sinensis; Moringa oleifera; white tea
Penulis: Amalia Rahma, Rina
Martini, Clara Meliyanti Kusharto, Evy Damayanthi, Dadan Rohdiana
Kode Jurnal: jpkesmasdd170533
