Melatonin menurunkan berat badan tetapi tidak menurunkan kadar TNF-α pada tikus wistar jantan yang diberi minyak jelantah selama 28 hari
Abstract: Non Alcoholic Fatty
Liver Disease (NAFLD) occurs when the intake and free fatty acid synthesis
occurs more frequently than its oxidation and resecretion in the blood.
Melatonin is a powerful antioxidant that can boost the synthesis of endogenous
antioxidants in the body, suppress the inflammatory response and inhibit the
formation of steatosis.
Objective: To analyze the effect of melatonin supplementation in reducing
body weight andTNF-α levels in male Wistar rats were fed by waste cooking oil.
Methods: True experimental studyusing post-test only control group
design. This study was done on 18 male wistar rats were divided into 3 groups :
the positive control group (P0) was administrated waste cooking oil, the
treated group 1 (P1) was administrated waste cooking oil and 5mg/kgBW
melatonin, and the treated group 2 (P2) was administrated waste cooking oil and
10mg/kgBW melatonin for 28 days.Data analysis using One Way ANOVA test and
followed by Tukey test to determine the most effective dose of melatonin.
Results: There was significant difference in body weightbetween P2group
and K0 group (p=0,019) with the mean body weight difference was 19,167g lower
than K0 group. There was no difference in TNF-α levels between the three groups
(p=0,155).
Conclusion: Melatonin dose of 10mg/kgBWloses body weight male Wistar rats
have given by waste cooking oil for 28 days, but does not reduce TNF-α levels.
Keywords: non-alcoholic fatty
liver, waste cooking oil, melatonin, TNF-α levels
Penulis: Anugrah Novianti, Edi
Dharmana, Nyoman Suci Widyastiti
Kode Jurnal: jpkesmasdd170479
