Aktivitas antihiperglikemia ekstrak kulit dan daun surian (Toona sinensis) pada tikus diabetes (Sprague-dawley) yang diinduksi streptozotocin
Abstract: This study aimed to
examine the antihyperglycemia activity of ethanol extract of 70% on surian bark
and leaves on diabetic rats induced with streptozotocin based on body weight,
and fasting blood glucose level. Consist of 28 rats are grouped into 7 groups
namely normal, negative control, positive control which given glybenclamide
with a dose of 3.22 mg/kg bw, bark extract with dose of 150 mg/kg bw, bark
extract with a dose of 300 mg/kg bw, leaf extract with dose 150 mg/kg bw and
leaf extract with dose 300 mg/kg bw. Diabetogenic mechanisms was conducted with
intraperitoneal injection of streptozotocin at
dose of 50 mg / kg bw. This research was conducted experimentally using
complete randomized design (RAL) to analyze the results obtained. Bark extract
with a dose of 150 mg/kg bw had a better antihyperglycemia activity compared to
the other groups which was showed by the decrease of blood glucose level
percentage of 72.83% and this group also had ability to maintain body weight
was better than the other groups as well as stable feed consumption during
research process.
Keywords: antihyperglycemia;
blood glucose; diabetic; surian
Penulis: Rori Theresia,
Syamsul Falah, Mega Safithri
Kode Jurnal: jpkesmasdd170487
