The Role of M2 Pyruvate Kinase in the Screening of Bowel Inflammation
Abstract: This is a study to
determine if M2 Pyruvate Kinase (M2-PK) can be used to screen the presence of
bowel inflammation.
Method: The study design being used is diagnostic test. In this study, we
recruited 76 participants and performed colonoscopy examination as a gold
standard and faecal M2-PK as the examined procedure.
Results: From the result of this study, we identified the important role
of M2-PK to screen the presence of bowel inflammation with the cut-off point of
1.05 U/mL compared to colonoscopy as gold standard with the sensitivity of
86.2%, specificity 81.8%, positive predictive value 96.6%, and negative
predictive value 50%.
Conclusion: From the result of this study, we suggested M2-PK examination
to screen bowel inflammation in patients with lower gastrointestinal tract
problems.
Keywords: M2 Pyruvate kinase;
colonoscopy; screening; intestinal inflammation
Author: Ruswhandi, Marcellus
Simadibrata, Irsan Hasan
Journal Code: jpkedokterangg150439
