The Immunogenicity and Safety of CYD-Tetravalent Dengue Vaccine (CYD-TDV) in Children and Adolescents: A Systematic Review
Abstract: to assess the
immunogenicity and safety of CYD-tetravalent dengue vaccine (CYD-TDV) in
children. Methods: comprehensive literature searches were conducted on various
databases. Randomized-controlled trials on children with CYD-TDV as
intervention were selected based on inclusion and exclusion criteria. Data
extracted from selected trials included safety of vaccine and immunogenicity in
terms of Geometric Mean Titres (GMT) of antibodies. Results: six clinical trials were selected based on
preset criteria. GMT values were obtained using 50% Plaque Reduction
Neutralization Test (PRNT) and safety was semi-quantitatively assessed based on
adverse effects. Additional data processing was done to obtain a better
understanding on the trends among the studies. The results showed that the
groups vaccinated with CYD-TDV showed higher immunogenicity against dengue
virus antigens than the control groups. Safety results were satisfactory in all
trials, and most severe side effects were unrelated to the vaccine. Conclusion:
CYD-TDV is both effective and safe for patients in endemic regions. This gives
promise for further development and large-scale research on this vaccine to
assess its efficacy in decreasing dengue prevalence, and its pervasive
implementation in endemic countries, such as Indonesia.
Keywords: Dengue;
Immunogenicity; Safety; CYD-TDV; Vaccine
Author: Raksheeth Agarwal,
Mardiastuti H Wahid, Oliver E Yausep, Sharon Hanmy Angel, Angga W Lokeswara
Journal Code: jpkedokterangg170335
