Role of Oxidative Stress on Chronic Kidney Disease Progression
Abstract: Chronic kidney
disease (CKD) is a worldwide health problem with a high incidence not only in
western countries but also in Indonesia as well. The majority of patients with
CKD died due to cardiovascular disease than CKD progression itself. In addition
to traditional risk factors, cardiovascular disease in CKD might also due to
non-traditional risk factors. Oxidative stress, as non-traditional risk
factors, is not only able to explain the high incidence of cardiovascular
disease in CKD, but also become a new target in therapeutic intervention.
Oxidative stress in patients with CKD appears due to increased oxidant
activity and decreased antioxidant system. Hemodialysis (HD) with the use of a
cellulose and semi-cellulose membrane also contribute to increase oxidant that
can activate the complement pathway. It stimulates inflammation that will
further expand the production of oxidants and will ultimately increase
oxidative stress.
Key words: chronic kidney
disease, oxidant, oxidative stress
Author: Alisia Y Putri,
Mochammad Thaha
Journal Code: jpkedokterangg140328
