Regulatory T Cell Immunity in Atherosclerosis
Abstract: Atherosclerosis is a
chronic inflammatory disorder involving innate and adaptive immunity process.
Effector T cell (Teff) responses promote atherosclerotic disease, whereas
regulatory T cells (Tregs) have been shown to play a protective role against
atherosclerosis by down-regulating inflammatory responses which include
multiple mechanisms. Compelling experimental data suggest that shifting the
Treg/Teff balance toward Tregs may be a possible therapeutic approach for
atherosclerotic disease, although the role of Tregs in human atherosclerotic
disease has not been fully elucidated. In this review, we discuss recent
advances in our understanding of the roles of Tregs and Teffs in experimental
atherosclerosis, as well as human coronary artery disease.
Keywords: Atherosclerosis;
regulatory T cells; inflammation
Author: Hilman Zulkifli Amin,
Naoto Sasaki, Ken-Ichi Hirata
Journal Code: jpkedokterangg170343
