Reactivation of Hepatitis B Virus Associated with Chemotherapy and Immunosuppressive Agent
Abstract: Hepatitis B virus
(HBV) reactivation after chemotherapy or immunosuppressive therapy is a serious
cause of liver-related morbidity and mortality. The mechanism of HBV
reactivation is still unclear, but it is believed due to the suppression of
immune response hence increasing the viral load. No uniform diagnostic criteria
are available, HBV reactivation can be confirmed by an increase in serum
HBV-DNA level. There are many consensus regarding this issue, including the
type and duration of nucleoside analogue therapy which need to be understood as
not all chronic hepatitis B patients will lead to HBV reactivation. Recently,
there has been an increased awareness of reactivation of occult hepatitis B
virus, especially in hepatitis B virus endemic area, including Indonesia as
part of Asia Pacific region. Preempative antiviral therapy was the best
approach to prevent the HBV reactivation.
Key words: hepatitis B virus
reactivation, chemotherapy, immunosuppressive
Author: Indra Wijaya, Irsan
Hasan
Journal Code: jpkedokterangg130284
