Hemostatic Status of Pre and Post Intracoronary Injection of Peripheral Blood Stem Cells in Patients with Recent Myocardial Infarction
Abstract: to investigate
hemostatic parameter changes, such as platelet aggregation, blood and plasma
viscosity, prothrombin time, APTT, CRP and fibrinogen, before and after
administration of stem cell therapy. Methods: a total of 24 patients were
enrolled. Peripheral blood stem cells (PBSCs) were harvested and injected into
the infarct-related artery after 5 consecutive days of G-CSF administration.
Recombinant human erythropoietin was administered at the time of intracoronary
PBSCs injection. Results: we were able to evaluate 11 from 24 of patients
regarding hemostatic status pre–post stem cell injection. There were no
significant difference between baseline vs 3 months in spontaneous aggregation
(p=0.350), PT (p=0.793), aPTT (p=0.255) and TT (p=0.254). There were also no
significant difference between baseline vs 3 months in plasma viscosity
(p=0.442) and blood viscosity (p=0.843). Nevertheless the patient who had their
blood and plasma viscosity above or below normal laboratory range return to
normal level after the treatment. Both PT and APTT also show normalization
value. Both Fibrinogen and CRP level show significant decrease between baseline
and 3 months after treatment (p=0.009) and (p=0.04) respectively. Conclusion:
combined G-CSF and EPO based-intracoronary infusion of PBSCs may open new
perspective in the treatment of hypercoagulable state post AMI.
Key words: coagulation,
platelet aggregation, myocardial infarction, hypercoagulation
Author: Cosphiadi Irawan,
Teguh Santoso, Djumhana Atmakusumah, Idrus Alwi, Agus Kosasih, Auda Aziz, Abdulmuthalib,
Lyana Lyana, Sri Inggriani, Ardian Saputra, Merry Wintery, Linda Lison, Ary H
Journal Code: jpkedokterangg140294
