Concordance between Reticulocyte Hemoglobin Equivalent and Reticulocyte Hemoglobin Content in CKD Patients Undergoing Hemodialysis
Abstract: to evaluate the
correlation and the concordance between reticulocyte hemoglobin equivalent
(RET-He) and reticulocyte hemoglobin content (CHr) as well as to obtain the
cut-off value of RET-He as the target of iron supplementation in chronic kidney
disease (CKD) patients undergoing hemodialysis. Methods: a cross-sectional
study was performed using K3EDTA-anticoagulated peripheral blood samples
collected from 106 CKD patients undergoing routine hemodialysis. The samples
were then analyzed using both Sysmex XN-2000 and Siemens ADVIA 2120i for RET-He
and CHr analysis. Results: a very strong correlation (r=0.91; p<0.0001) and
a good concordance were found between RET-He and CHr with mean bias of 0.5 pg.
The diagnostic concordance was 96.23%. The cut-off value of RET-He 29.2 pg was
obtained from the receiver operating characteristic (ROC) curve with CHr as the
gold standard. At this cut-off point, the sensitivity and specificity to assess
the target of iron supplementation in CKD patients undergoing hemodialysis were
95.5% and 94%, respectively. Conclusion: the study shows a good correlation and
concordance between RET-He and CHr in CKD patients undergoing hemodialysis.
Keywords: reticulocyte
hemoglobin content (CHr); reticulocyte hemoglobin equivalent (RET-He);
hemodialysis patient
Author: Riadi Wirawan, Ailinda
Theodora Tedja, Fify Henrika, Aida Lydia
Journal Code: jpkedokterangg170337
