Vitamin C Intakeand Risk Factors for Knee Osteoarthritis
Abstract: Knee osteoarthritis
(OA) is a degenerative disease of the knee joints characterized by progressive
softening and disintegration of articular cartilage. In OA, which is influenced
by several risk factors, free radicals are increased by local ischemia in the
cartilage. As an exogenous antioxidant, vitamin C also plays an important role
in collagen and glycosaminoglycan synthesis. This study was carried out to
identify vitamin C intake as well as risk factors in knee OA.
Methods: The study population was determined by non-probability sampling
with convenient approach to knee OA patients at the Rheumatology Outpatient
Clinic of Dr. Hasan Sadikin General Hospital in October–November 2013. Data
were obtained through questionnaire interview about risk factors, severity
index of OA and vitamin C intake profile. Data presentation was conducted by
descriptive method.
Results: There were 47 patients diagnosed with knee OA in the
Rheumatology Outpatient Clinic. The result showed that 7 patients (14.9%) had
low vitamin C intake for the last 3 months. There were 30 patients with family
history of OA (63.8%). Thirty two patients (68.1%) were passive smokers, 44
patients (93.6%) had history of repeated use of knee joints and majority of
respondents had obesity.
Conclusions: Most of the subjects have sufficient vitamin C intake and
more than half have risk factors that may contribute to the incidence of knee
OA.
Keywords: Knee osteoarthritis,
risk factors, vitamin C intake
Author: Nadia Ayu Destiani,
Siti Nur Fatimah, Sumartini Dewi
Journal Code: jpkedokterangg170108
