Triiodothyronine levels and mortality in children with sepsis and septic shock
Abstract: Sepsis is the most
common cause of death in infants and children. It can cause hormonal
imbalances, such as euthyroid sick syndrome (ESS), which may increase the risk
of death.
Objective To evaluate a possible correlation between the level of
triiodothyronine (T3) and mortality in children with sepsis and septic shock.
Methods An observational cohort study was conducted on 80 children with
sepsis and septic shock from October 2015 until January 2016 in Haji Adam Malik
General Hospital, Medan. Subjects underwent PELOD score and T3 examination on
the first day admitted in Haji Adam Malik General Hospital. Chi-square test was
used to analyze for a correlation between the T3 values and mortality.
Results Of the 80 consecutive subjects, 39 (48.75%) had low T3 level on
the first day. Of these 39 children, 36 (92.3%) died. Subjects with low T3
level had a 6.31 times higher risk of mortality(PR 6.31; 95%CI 2.99 to 13.28; P<0.001). Of the 31
subjects with high PELOD score, 23 (74.2%) had decreased T3 (PR=2.27; 95%CI
1.45 to 3.57; P<0.001).
Conclusion Low T3 level has significant relationship with mortality in
children with sepsis and septic shock.
Keywords: triiodothyronine; mortality;
sepsis; septic shock
Author: Cynthea Prima
Destariani, Munar Lubis, Melda Deliana, Gema Nazri Yanni
Journal Code: jpkedokterangg180017
