Third trimester maternal 1,25-dihydroxyvitamin D and neonatal birth weight
Abstract: The main cause of
neonatal mortality is low birth weight. Active form of vitamin D
(1,25-dihydroxyvitamin D) increase the efficiency of calcium and phosphorous
absorption in intestinal. Deficiency 1,25-dihydroxyvitamin D in pregnant woman
was hipothesized relates with low birth weight in neonate.
Objective To determine the relationship between maternal
1,25-dihydroxyvitamin D level and neonatal birth weight.
Methods This was an observational study with cohort design to 47 women in
the third trimester pregnancy. This study was cond ucted on August to December 2014. Subjects
were taken from Ibu dan Anak Hospital, Padang, West Sumatera. Maternal blood
from antecubital vein was examined for 1,25-dihydroxyvitamin D concentration
using enzyme-linked immunosorbent assay (ELISA). Neonatal birth weights were
measured right after delivery. Data were
analyzed by Pearson’s correlation and linear regression tests.
Results A positive correlation was found between maternal
1,25-dihydroxyvitamin D level and neonatal birth weight (R=0.910; R2=0.821;
P=0.000). The 1,25-dihydroxyvitamin D level had an 82.1% contribution to the
baby’s birth weight, while other factors not assessed in this study had less of
an effect.
Conclusion There was positive correlation between maternal
1,25-dihydroxyvitamin D levels in the third trimester of pregnancy and neonatal
birth weight
Keywords: 1,25-dihydroxyvitamin
D; low birth weight; materna; neonatal
Author: Yusrawati, Meldafia
Idaman, Nur Indrawati Lipoeto
Journal Code: jpkedokterangg170168
