The Pathogenesis of Atopic Dermatitis: The Role of Filaggrin
ABSTRACT: Atopic dermatitis
(AD) is a multifactorial skin disease with waxing and waning inflammatory
process. In recent years, genetic mutations namely the null mutations of the
filaggrin gene (FLG) has been the focus in AD risk factors investigations.
Purpose: To highlight the emerging topic on the role of filaggrin as an
important element in the pathogenesis of AD. Reviews: Filaggrin binds to
cytoskeleton keratin to bring the physical strength to corneocytes. Filaggrin
will be degraded to amino acids that conserve acidic pH and condensation of the
skin. Patients with FLG null mutations are more likely to experience
early-onset, severe and persistent AD. AD patients with FLG R501X null
mutations are reported to be the least responsive to therapy. Conclusion: A
filaggrin deficit is the main culprit in AD development that eventually leads to
the defective skin barriers, reduction in natural moisturizing factors (NMF),
infections and inflammation. FLG mutations associates with the phenotypes and
course of AD which could be examined using Raman-determined NMF.
Penulis: Tamarachiara
Kuntjoro, Erna Harijati
Key words: atopic dermatitis,
filaggrin, loss-of-function (null) mutations
Kode Jurnal: jpkedokterandd170494
