The effect of hemofilter, preoperative and intraoperative methylprednisolone on complications after open heart surgery
Abstract: Complications after
open heart surgery may threaten patient’s survival rate. The administration of
intraoperative methylprednisolone alone shows controversial results on open
heart surgery complications. The administration of intraoperative and
preoperative methylprednisolone and the use of hemofilter in open heart surgery
is still controversial. This study aimed to understand the effect of
hemofilter, preoperative and intraoperative methylprednisolone on complications
following open heart surgery. This study was a Prospective Randomized
Open-Blinded Evaluation (PROBE) experimental study. We ascertained 95 patients
who had open heart surgery in Dr. Sardjito Hospital, Yogyakarta, and Integrated
Cardiac Care of Dr. Cipto Mangunkusumo Hospital, Jakarta within the period of
December 2011 to May 2012. The patients were divided into two groups: group A
(48 patients) received intraoperative methylprednisolone (15mg/kg),
preoperative methylprednisolone (5mg/kg), and hemofilter; while group B (47
patients) received an intraoperative methylprednisolone (15mg/kg) alone. From
the total 95 samples, we found 26 (27.4%) samples experienced complications; 19
in group B (40.4%) and 7 in group A (14.6%). The differences were statistically
significant with p value of 0.005 (OR=3.97; 95%CI=1.476-10.71). Complications
risk decreased by 63.9% in group A compared to group B with the hazard ratio of
3.2. In conclusion, the application of hemofilter, preoperative and intraoperative
methylprednisolone might decrease the risk of complications after open heart
surgery.
Keywords: hemofilter,
methylprednisolone, complication, open heart surgery
Author: FNU Supomo
Journal Code: jpkedokterangg170289
