The Effect of Flaxseed Ethanolic Extract on the Structure of the Kidney and the Endocrine Pancreas in Streptozotocin Induced Diabetic Rats
Abstract: The present
investigation has been designed to study the possible protective effect of
flaxseed extract on the structures of the endocrine pancreas and kidneys of
streptozotocin (STZ) induced diabetic rats for 30 days. Methods: Forty male
Sprague-Dawley rats were randomized into five groups (n=8). Normal control
group (NC); received distilled water orally, normal flaxseed group (NF);
treated orally with (400 mg/kg) extract of flaxseed, diabetic control group
(DC); treated with single intraperitoneal dose of STZ (60 mg/kg), diabetic
flaxseed group (DF); diabetic rats treated with extract of flaxseed (400
mg/kg), diabetic glibenclamide group (DG); diabetic rats treated with (0.6
mg/kg) glibenclamide. Results: Histological observation of sections in pancreas
in DC group revealed shrunken islets of Langerhans with degenerated and degranulated
β-cells, vacuolations and congested capillaries while sections of kidneys
showed shrinkage of some glomeruli and degeneration of others with wide urinary
space and hydropic degeneration in some tubular epithelial cells, dilated
tubules and cell debris scattered in tubular lumina. These pathological changes
were ameliorated in the flaxseed extract and glibenclamide treated rats.
Conclusions: It is concluded that flaxseed extract may represent a good
alternative treatment for management of diabetes and its related complications
such as diabetic nephropathy.
Keywords: diabetes mellitus,
endocrine, pancreas, kidney, flaxseed streptozotocin
Author: Imad Matloub Al-Ani,
Ghassan A Al-Ani, Marwan S Azzubaidi, Basma I Al-Ahmed
Journal Code: jpkedokterangg170250
