The Antidiabetic Activity of Curry Leaves “Murraya Koenigii” on the Glucose Levels, Kidneys, and Islets of Langerhans of Rats with Streptozotocin Induced Diabetes
Abstract: The aims of this
study were to explore the antihyperglycemic effect of curry leaves, Murraya
koenigii "MK" aqueous extract, and to examine its possible protective
effects on the islets of Langerhans and kidneys of streptozotocin (STZ)
diabetic rats. Methods: Thirty healthy adult male Sprague Dawley rats were randomized
into five groups (n=6); normal control, normal treated with "MK"
control, diabetic control (non-treated with "MK"), diabetic treated
with 200 mg/kg MK aqueous leaf extract and diabetic treated with 400 mg/kg MK
aqueous leaf extract. Blood glucose levels and body weight were monitored
gravimetrically. The animals were sacrificed on the 30th day; the kidney and
pancreatic tissues were processed for histological studies. Results: The
diabetic group showed considerable loss of body weight and increase in blood glucose
levels and degeneration of the glomeruli and renal convoluted tubules and
atrophied islets with disintegration of β-cells. Treatment of diabetic rats
with MK extract showed significant (p < 0.001) improvement in blood glucose
levels and body weight gain. The MK extract also caused an improvement in
tissue injury induced by STZ injection in the kidney and islets of Langerhans.
Conclusions: These findings highlighted the beneficial effects of MK aqueous
extract against cellular oxidative damage in STZ-induced diabetic rats.
Keywords: Blood glucose; Body
weight; Curry leaves; Islet of Langerhans; Kidney
Author: Imad M Al-Ani, Rahajoe
I Santosa, Muhammad H Yankuzo, Anil K Saxena, Khalid S Alazzawi
Journal Code: jpkedokterangg170252
