Smoking cessation reduces ratio of total cholesterol/high density lipoprotein (HDL) cholesterol levels on adult people in Yogyakarta Special Region
Abstract: Cigarette smoking is
a major cause of cardiovascular disease due to elevation of free radical
substances as well impairment in lipid metabolism. Smoking cesation has been
linked with reduced risk of mortality. However, data regarding cardiovascular
disease (CVD) risk factor in former smoker is limited. The aim of the study was
to evaluate the CVD risk factor among smoker, non-smoker and former smoker in
Yogyakarta Special Region, Indonesia. A cross-sectional design from 86
apparently healthy male, aged between 25-50 years old was performed for this
study. From total subjects, 45 subjects are smokers, 26 are non-smokers and 15
are former smokers. Body weight, height, and blood pressure were also measured
from the subjects. Blood was drawn for assessment of total cholesterol (TC),
triglyceride, low density lipoprotein (LDL), high density lipoprotein (HDL) and
C-reactive protein (CRP) concentrations. We found significant difference in the
level of HDL, cardiovascular risk index (LDL/HDL ratio), atherogenic index
(TC/HDL ratio) and also in systolic blood pressure among groups (p<0.05).
Smoking person had significantly low HDL level with high CVD risk index and
atherogenic index (p<0.05). The CVD risk index was not different between
former smoker and smoker groups. Serum CRP level was not different among the
groups. In conclusion, smoking is associated with increased risk of CVD.
Smoking cessation slightly decrease the CVD risk.
Author: Arta Farmawati
Journal Code: jpkedokterangg170291
