Serum 25-hydroxyvitamin-D level and atopic dermatitis severity in children
Abstract: Vitamin D plays an
important role in the immune system. It inhibits B-lymphocyte proliferation and
modulates the humoral response to suppress IgE production. Studies on the
relationship between serum 25-hydroxyvitamin-D level and the severity of atopic
dermatitis in several countries have had varying results.
Objective To assess for a possible correlation between serum
25-hydroxyvitamin-D level and atopic dermatitis severity in children.
Methods A cross-sectional study was conducted in 26 children with atopic
dermatitis from September to December 2015. We evaluated the severity of
disease using the Scoring of Atopic Dermatitis (SCORAD) index and measured
serum 25-hydroxyvitamin-D levels. Spearman’s test was used to analyze for a
correlation between serum 25-hydroxyvitamin-D level and the atopic
dermatitis score in children with atopic
dermatitis.
Results Mean SCORAD index was 32.0 (SD 14.99) , with a range of 10.9 to
71.4. Mean serum 25-hydroxyvitamin-D level was 41.1 (SD 24.81) ng/mL, with a
range of 10-137 ng/mL. There was a moderate correlation between serum
25-hydroxyvitamin-D level and the SCORAD index (r=-0.591), with higher SCORAD
index associated with lower serum 25-hydroxyvitamin-D level (P=0.01).
Conclusion There is a moderate correlation between serum
25-hydroxyvitamin-D level and the SCORAD index in children with atopic
dermatitis.
Keywords: atopic dermatitis;
vitamin D; children
Author: Laily Munawwarah, Rita
Evalina, Sri Sofyani
Journal Code: jpkedokterangg170070
