Pathogen Profile of Patients with Sepsis in Internal Medicine, Dr. Hasan Sadikin General Hospital, Bandung 2013
Abstract: Sepsis is a
continuous disease which begins with systemic inflammatory response syndrome
(SIRS), seen in association with a large number of clinical conditions. These
include infectious insults that produce SIRS, such as pancreatitis, ischemia,
multiple traumas and tissue injury, hemorrhagic shock, immunemediated organ
injury, and the exogenous administration of such putative mediators of the
inflammatory process as tumor necrosis factor and other cytokines. A frequent
complication of SIRS is the development of organ system dysfunction, including
such well-defined clinical conditions as acute lung injury, shock, renal
failure, and multiple organ dysfunction syndrome (MODS). Hence, this study was
conducted to identify the pathogen profile that often causes sepsis.
Methods: A retrospective study was performed to 152 medical records of
patients diagnosed as sepsis from Internal Medicine Department Dr. Hasan
Sadikin General Hospital from January 2013 to December 2013. The variables
observed from the medical records were age, sex, comorbidity, main infection,
culture sample, type of gram bacteria, resistant bacteria, and antibiotic
susceptibility test. After data collection was completed, the data were
analyzed using computer. The data were presented in percentage.
Results: Sepsis in male was higher than female. Highest comorbid was
chronic kidney disease (CKD). The main infection was health care acquired
pneumonia (HCAP). Highest pathogen that caused sepsis was Escherichia coli and
highest multidrug-resistant organism (MDRO) was extended spectrum
beta-lactamase (ESBL) Escherichia coli.
Conclusions: The most common pathogen that causes sepsis is Escherichia
coli.
Keywords: Chronic kidney
disease, Escherichia coli, sepsis
Author: Afiq Syazwan Fauzi,
Uun Sumardi, Nina Tristina
Journal Code: jpkedokterangg160236
