Mixed Lung Cancer in 46 Years Old, Male Smoker, Untreated Patient
Abstract: Lung cancer is a
large heterogeneous family of malignancies, with tumors containing more than
one subtype are very common. Over 50 different histological variants are
recognized within the WHO typing system. Small Cell Lung Cancer comprises
approximately 20% of all lung cancers and exhibits a neuroendocrine phenotype
while Non Small Cell Lung Carsinoma (NSCLC) lacks these features and makes up
the remaining 80% of cases. This case was reported in view of the rarity of
this combination of morphologic patterns. The incidence of c- SCLC (Combined-
Small Cell Lung Carsinoma) has been reported ranging from less than 1% to 14.6%
of all SCLC. Mixed lung cancer in untreated patients suggests a common
endodermal origin for c-SCLC which contains small-cell and non-small-cell
pulmonary tumors. Quoix et al found that presentation as a solitary pulmonary
nodule (SPN) is particularly indicative of a c-SCLC. Combined- Small Cell Lung
Carsinoma contains a squamous cell and/or adenocarcinoma component. It’s
becoming more important for pathologists to correctly subclassify NSCLC’s as
distinct tumor entities, or as components of c-SCLC cause it’s more agrresive.
A 46-year-old smoker man was referred because of rapid growth of a solitary
nodule mass revealed by chest radiography with brain and limfonodes metastases.
There was mixed histological feature including adenocarsinoma, squamous cell
carsinoma and large cell carsinoma. The patient is dead after a few weeks
later. It was revealed a panel immunohistochemistry stain (CK-7, CK-20, TTF-1,
P63 and Chromoganin). It was concluded as c- SCLC.
Keywords: Mixed lung cancer;
combined Small Cell Lung Carsinoma (c-SCLC); solitary nodul
Author: Susilorini, Dik Puspasari, Siti Amarwati,
Bambang Endro
Journal Code: jpkedokterangg160202
