INFLUENCE OF DIABETES MELITUS, BMI, AND HBA1C IN HIGH GRADE PROSTATE CANCER
Abstract: This study aims to
determine the effect of diabetes mellitus (DM) and body mass index (BMI) on the
risk of prostate cancer and high grade prostate cancer. Materials & method:
This study is a retrospective observational study with cross-sectional design,
using secondary data to determine the relationship of diabetes mellitus, body
mass index and HbA1c levels with the degree of differentiation histopathologic
prostate cancer. Data were analyzed using Chi-Square test, T-test and Man
Whitney test with a confidence level of p<0.05 and a=0.05. Results: There
are 78 samples diagnosed with prostate cancer. A total of 12 (15.4%) samples
are diabetes mellitus, 18 (22.9%) samples classified as body mass index more than
23.4 (5.1%) samples have elevated levels of HbA1c levels >6.5. On
histopathologic examination, it was found as many as 45 (57.7%) samples with
high grade prostate cancer, as much as 9 (11.5%) samples with moderate grade
prostate cancer, and as many as 24 (30.8%) samples with low grade prostate
cancer. In bivariate analysis diabetes mellitus, BMI>23, and HbA1c level
relationship with high grade prostate cancer is not statistically significant
with p>0.05. Conclusion: There were no statistically significant relationship
between diabetes, BMI and increased levels of HbA1c with high grade prostate
cancer.
Keywords: Diabetes; body mass
index; HbA1c; prostate cancer
Author: exsa hadibrata, H R
Danarto
Journal Code: jpkedokterangg170019
