Increased matrix metalloproteinase-9 in male elderly with low 25-hydroxy-vitamin D
Abstract: One of the
extra-skeletal roles of vitamin D for health is associated with cardiovascular
disease. Poor vitamin D status has been associated with vascular endothelial
dysfunction. There were controversial results about the association between
vitamin D deficiency and matrix metalloproteinase 9 (MMP-9) concentration. The
purpose of the present study was to determine the concentrations of 25(OH)
vitamin D [25(OH)D] in an elderly population and to find any association
between 25(OH)D and MMP-9 concentrations.
Methods
This study was of cross-sectional design involving 160 male and female
subjects aged 55–65 years, in South Jakarta, Indonesia. Determination of MMP-9
and 25(OH)D concentrations was done concurrently on subjects who met the
inclusion and exclusion criteria after all study subjects had been selected.
25(OH)D and MMP-9 concentrations were assessed by direct competitive
chemiluminescence immunoassay (CLIA) and enzyme-linked immunosorbent assay
(ELISA) respectively. Statistical analysis used chi square and t tests.
Results
Mean 25(OH)D concentration in the study subjects was 14.4 ± 6.4 ng/mL. A
total of 68.8% of subjects had a 25(OH)D level of <20 ng/mL, and 31.2 % had
a 25(OH)D level of >20 ng/mL.There was an increased MMP-9 concentration in
male subjects with a 25(OH)D level of <20 ng/mL compared with subjects with
25(OH)D level of >20 ng/mL (p=0.011), but not among female subjects
(p=0.809).
Conclusion
The MMP-9 concentration was increased among male subjects with low level
of (OH)D. This study confirmed that 25(OH)D concentration may have a potential
role in endothelial function.
Keywords: Endothelial
function, MMP-9; 25(OH)D; vitamin D deficient; elderly
Author: Pusparini, Lie Tanu
Merijanti, Novia I. Sudharma
Journal Code: jpkedokterangg160216
