Hepatitis B seroprotection in children aged 10-15 years after completion of basic hepatitis B immunizations
Abstract: The prevalence of
hepatitis B viral (HBV) infection in Indonesia is high. The most effective way
to control HBV infection is by hepatitis B (HB) immunization. Many studies
reported that hepatitis B surface antibody (anti-HBs) seroprotection declines
in children > 10 years of age. In addition many factors can influence
anti-HBs titer.
Objective To measure anti-HBs titer and evaluate possible factors
associated with anti-HBs titer.
Methods This cross sectional study
was conducted in children 10-15 years of age from ten schools at Tuminting
District, Manado, North Sulawesi, from October to November 2014. All subjects
had completed the hepatitis B immunization scheme. By stratified random
sampling, 105 children were selected as subjects. Data was analyzed with SPSS
version 22.
Results. From 48 schools, we selected 10 schools from which to draw a
total of 105 children, but only 23 (21.9%) children had detectable anti-HBs .
Of all subjects, 76 (72.4%) were female,
78 (74.3%) had good nutritional status,
and 98 (93.3%) had birth weight ≥2,500
grams. Data from immunization record books showed that 26 (24.8%) subjects
received the HB-1 vaccination at ≤7 days of age and 45 (42.9%) subjects had a
≥2 month interval between the HB-2 and HB-3 vaccinations. Multivariate analysis
showed that administration of HB-1 at ≤7 days of age and a ≥2 month interval between HB-2 and
HB-3 had significant associations with
anti-HB seroprotection in children.
Conclusion A low proportion of subjects who had completed the hepatitis B
immunization scheme had detectable anti-HBs titer (21.9%). Administration of
HB-1 at ≤7 days of age and a ≥2-month interval between HB-2 and HB-3
vaccinations are important factors in anti-HB seroprotection in children aged
10-15 years.
Keywords: Seroprotection,
anti-HBs titer, factors influenced anti-HBs titer
Author: Novie Homenta
Rampengan, Sri Rezeki Hadinegoro, Mulya Rahma Karyanti
Journal Code: jpkedokterangg170074
