GEL FORMULATION OF ETHANOL EXTRACT OF MANGOSTEEN PEEL (GARCINIA MANGOSTANA L.) AS A MEDICATION FOR BURNS IN WISTAR RATS
Abstract: Mangosteen peel
(Garcinia mangostana L.) has been shown to stimulate the regeneration of
damaged body cells and have an antimicrobial activity that can be beneficial in
healing burns. Therefore, it is necessary to make it into a gel dosage form
that has the advantages of being easily washed with water, high adhesion,
cooling of the skin, and good drug release.
Objective: To determine the effect of varying concentrations of ethanol
extract of mangosteen peel in a gel formulation on wound healing in burns and
the physical properties of the gel.
Methods: Mangosteen peel extract was obtained by maceration method using
ethanol 70%. This extract was formulated in a gel dosage form with variations
of extract concentration, namely F I (5%), F II (10%), and F III (15%). The
gels were then tested for their physical properties (organoleptic, homogeneity,
pH, spreadability, adhesiveness, and physical stability) and their activity
against burns experimentally using mice as test animals. Burns were made by
using a hot plate with an area of 2 cm x 2 cm.
Results: The increase of extract concentration could increase
spreadability (p>0.05), adhesiveness (p>0,05), and percentage of healing
activity against burns as shown by a significant difference between FI and
FIII. On the other hand, the difference in the concentration of the extract did
not affect pH (all formulations have pH of 3.5); all formulas also remained
homogenous and stable after centrifugation.
Conclusion: The best physical properties and wound healing activity for
burns was shown by the gel with the ethanol extract of mangosteen peel at a
concentration of 15%.
Keywords: Gel Burns Physical
properties Mangosteen peel extract
Author: Nining Sugihartini
Journal Code: jpkedokterangg170273
