Effectiveness of ferric sodium edentate supplementation in children with lead poisoning
Abstract: Lead is a harmful
toxin that affects human health worldwide, especially in children. Lead
poisoning remains a global problem both in developed and developing countries.
The Centers for Disease Control and Prevention (CDC) recommends nutritional
intervention with iron supplementation to efficiently control high lead levels.
Iron supplementation in the form of sodium ferric ethylene-diaminetera-acetic
acid/ ferric sodium edentate (NaFeEDTA) is highly bioavailable.
Objective To determine the effectiveness of ferric sodium edentate
(NaFeEDTA) on lead levels in children woaj ;ead [pospmomg.
Methods This interventional,
analytical study, had a one group pretest-posttest design, and was done on
children in four elementary schools in the Talawaan District, North Minahasa
Regency from August to November 2014. Inclusion criteria were elementary students
aged 6-9 years with lead poisoning (lead levels ≥ 10 μg/dL) and good
nutritional status. Subjects were given
NaFeEDTA 115.4 mg (15 mg elemental iron) at a dosage of 3 mg/kgBW/day elemental
iron given between meal times. Iron supplementation was given daily per oral
route for 12 weeks. Descriptive analysis
was used to analyze the characteristics of the study sample. Pre- and post-test
analyses were done with paired T-tests. Significance level was P <0.05.
Results In this study, 39 children met the inclusion criteria and
consisted of 19 boys and 20 girls. Their mean age was 8.43 (SD 0.44) years.
Pre-test and post-test blood lead levels was 36.18 μg/dL and 5.22 μg/dL,
respectively.There was a significant reduction in mean blood lead levels after
administration of NaFeEDTA (P <0.0001).
Conclusion In children with lead poisoning, blood lead levels are
significantly reduced after 12 weeks of NaFeEDTA supplementation.
Keywords: lead poisoning;
blood lead levels; NaFeEDTA
Author: Praevilia Salendu,
Nurhayati Masloman, Sarah M. Warouw
Journal Code: jpkedokterangg170184
