Effect of ethanol extract of Syzygium cumini (L.) pulp on blood pressure and malondyaldehyde level of chronic restraint stress rats
ABSTRACT: Chronic stress
disturbs the equilibrium of oxidant-antioxidant redox in the human body which
accelerates cellular aging. This condition promotes earlier onset of
age-related diseases. Human body needs exogenous antioxidant to fight stress.
Syzigium cumini has high antioxidant activity because it’s rich in anthocyanin.
It has potential to become natural antioxidant source thus it needs to be
developed.
Aim. This study aims to investigate the effect of Syzigium cumini (Pulp)
extract on the stress biomarkers which are Malondialdehyde and blood pressure
in rat induced by restraint stress.
Method. Chronic stress phase is conducted with male Wistar rats (n=20)
which were divided into 4 groups (normal control, negative control, and two
treatment groups with the ethanol extract of Syzygium cumini (Pulp) at 20
mg/200 gram and 40 mg/200 gram body weight). Restraint stress was carried out
by placing the animal in narrow tube for 30 minutes daily (7 days). Blood
pressure was evaluated before and after the treatment while Malondialdehyde was
evaluated after the treatment. The One-way ANOVA was used to analyze the
parameters.
Results. Based on chronic stress phase, treatment groups show significant
result in preventing the increase in blood pressure (P < 0,001). The
increased levels of Malondialdehyde were prevented significantly in all
treatment groups (P < 0,001)
Conclusion. In chronic stress phase, Syzygium cumini (Pulp) extract can
become an antihypertensive agent. Syzygium cumini (Pulp) extract shows an
effect in decreasing lipid peroxidation products. This result shows that the
Syzygium cumini (Pulp) extract has potent antioxidant function.
Keywords: Syzigium cumini,
restraint stress, malondialdehyde, MDA, blood pressure
Author: Mega Febia
Suryajayanti
Journal Code: jpkedokterangg170295
