Decreased adiponectin level in adults with central obesity and low 25-hydroxy vitamin D level
Abstract: Vitamin D
insufficiency is associated with obesity and central obesity, which is in turn
associated with the accumulation of visceral fat. Visceral fat secretes
adiponectin which has a role in the pathogenesis of the metabolic syndrome,
diabetes mellitus and cerebrovascular disease. The aim of this study was to determine
the relationship between serum 25-hydroxy vitamin D [25(OH)D] level and
adiponectin level in adults with central obesity.
Methods
This study was a cross sectional study with 80 subjects with central
obesity and 80 healthy subjects as controls. The age of the subjects ranged
from 55 to 65 years. The data collection included anthropometry and blood
biochemistry (lipid profile, fasting blood glucose, 25(OH)D, and adiponectin).
The data were analyzed using independent t test with p <0.05.
Results
Mean waist circumference and 25(OH)D level in the central obesity group
were 94.9 ± 7.8 cm and 14.3 ± 6.6 ng/mL, respectively, and in the control group
72.4 ± 5.0 cm and 19.2 ± 8.6 ng/mL respectively. There were significant
differences in adiponectin level between the central obesity group and the
control group at the 25(OH)D level of <20 ng/mL (p=0.001), but no
significant differences between the two groups at the 25(OH)D level of ³20
ng/mL (p=0.538).
Conclusion
The central obesity subgroup with 25(OH)D level of <20 ng/mL have
lower adiponectin levels compared with the control group. This study
demonstrates the role of adiponectin as a link between insulin resistance and
vitamin D status in adults.
Keywords: Vitamin D
deficiency; central obesity; adiponectin; adult
Author: Pusparini, Lie Tanu
Merijanti, Alvina Lesmana, Meiyanti
Journal Code: jpkedokterangg170050
