Comparison of inflammation and oxidative stress levels by the severity of obesity in prepubertal children
Abstract: Children with severe
obesity are more likely to develop diabetes and cardiovascular diseases at a
younger age. Inflammation and oxidative stress associated with childhood
obesity may be important in the development of insulin resistance and
atherosclerosis.
Objective To compare levels of high-sensitivity C-reactive protein
(hsCRP) and malondialdehyde (MDA) by the severity of obesity in prepubertal
children aged 6 to 10 years.
Methods We conducted a cross-sectional study at the Pediatric Nutrition
and Metabolic Syndrome Clinic, Sanglah Hospital, Bali, from August to December
2015. Subjects were categorized into three body mass index (BMI) groups,
according to the 2000 Centers for Disease Control and Prevention growth chart:
overweight (85th-94.9th percentile), obese (95th-98.9th percentile), or
severely obese (≥ 99th percentile). Plasma MDA and serum hsCRP were analyzed in
blood specimens obtained at enrollment. Data were analyzed by Kruskal-Wallis
test, followed by Mann-Whitney U test for post-hoc comparison between groups.
Results Subjects were 20 overweight children, 29 obese children, and 28
severely obese children. Levels of MDA were significantly higher in the
severely obese [median 0.25 (IQR 0.1) μmol/L] than in obese subjects [median
0.19 (IQR 0.1) μmol/L; P=0.001], and than in overweight subjects [median 0.16
(IQR 0.1) μmol/L; P<0.0001]. Also, the severely obese children had
significantly higher hsCRP levels compared to obese [median 3.2 (IQR 2.0) mg/L
vs. 1.3 (1.6) mg/L, respectively; P<0.0001] and compared to overweight
children [median 0.7 (IQR 0.6) mg/L; P<0.0001].
Conclusion Prepubertal children at the ≥ 99th percentile for BMI
(severely obese) are more likely to have significantly higher hsCRP and MDA
compared to those in the obese and overweight groups.
Keywords: obese; children;
MDA; hsCRP
Author: Ni Luh Putu Surya
Candra Eka Pertiwi, I Gusti Lanang Sidiartha
Journal Code: jpkedokterangg170211
