BACTERIAL ISOLATES AND ANTIMICROBIAL SUSCEPTIBILITY IN CHILDREN WITH ACUTE DIARRHEA AT IBN SINA MEDICAL COLLEGE, BANGLADESH
Abstract: Infectious diarrhea
is one of common cause of children diarrhea causing mortality and morbidity
worldwide. This study was performed to identify the common bacteria and their
antimicrobial susceptibility in children with diarrhea. Methods: A
retrospective study was conducted from April 2014 to March 2016 at IBN SINA
Medical College Hospital, Bangladesh. Stool samples were cultured on MacConkey
agar and blood agar. A standard biochemical procedure was used for full
identification of bacterial isolates. Antimicrobial susceptibility tests were
done on Mueller-Hinton agar by using disc diffusion method. Data were entered
and analyzed by using SPSS version 20 and a p-value of < 0.05 was considered
statistically significant. Results: A total of 186 stool samples were tested
for bacterial isolation and 55 (29.57%) cases were found to have bacterial
isolates. From the total bacterial isolates, the predominant isolate was E.
coli 39 (70.91%) followed by Salmonella 9 (16.36%) and Shigella Spp.7 (12.73%).
As much as 84.62% E. coli were resistant to co-trimoxazole and cefuroxime while
92.31% E. coli were sensitive to amikacin and 71.79% were sensitive to cefepime
and gentamicin. Salmonella were 100% sensitive to cefepime, ceftriaxone,
cefixime, ceftazidime, and ciprofloxacin. Shigella were 85.71% sensitive to
amikacin and cefepime.
Conclusion: The results show that E. coli were the most frequently
isolated pathogen in children. The majority of the bacterial isolates were
resistant to multiple antibiotics. Hence, antibiotics susceptibility test is
mandatory before prescribing any antibiotics.
Keywords: diarrhea, drug,
resistance, antibiotic
Author: Sonia Akter
Journal Code: jpkedokterangg170269
