STUDY ON THE EFFECT OF POLLUTANTS ON THE PRODUCTION OF AAPTAMINES AND THE CYTOTOXICITY OF CRUDE EXTRACT FROM Aaptos suberitoides
Abstract: This experiment was
conducted to study the effects of anthropogenic stressor on the spatial variability
of secondary metabolites from marine sponge Aaptos suberitoides. Samplings wereconducted
at 7 sites in Marine National Park of Thousand Islands that are extended within
30 km off Jakarta bay on late February 2011. Sponges were collected and
quantified by means of liquid chromatography coupled with photo-diode array
detection, whereas, cytotoxicity of sponges extracts was determined against
T47D (breast) cancer cell lines. Results showed that the spatial production of
aaptamine and isoaaptamine did not correlate with the quality of their
surrounding habitat, despite nitrite and nitrate levels significantly affected
the bioactivity of crude extracts.
Keywords: A. suberitoides,
aaptamines, spatial production, cytotoxicity, pollutants
Author: Ariyanti Suhita Dewi,
Tri Aryono Hadi, Hedi Indra Januar, Asri Pratitis, Ekowati Chasanah
Journal Code: jpperikanangg120008
