Properties of Sodium Alginate–Polyvinyl Alcohol Hydrogels Irradiated By Gamma Ray For Wound Dressing Materials
Abstract: A copolymer of
sodium alginate (SA)–polyvinyl alcohol (PVA) was synthesized by gamma
irradiation to make a hydrogel
and study on its properties has been carried out.
A series of 0.5% -2.0% (w/v) of SA
solution and 10% (w/v) of PVA solution were prepared in separate tubes. Each of
the SA solution was mixed with PVA solution, then it was irradiated with gamma
ray at the doses of 30 kGy, 40 kGy, and 50 kGy (dose rate of 10 kGy/hour),
respectively. The properties of hydrogels were evaluated comprising of the
physical performance, gel fraction, swelling ratio, water evaporation, and pH.
The results showed that increase of irradiation dose can increase the gel fraction,
but increase of SA concentration can
decrease the gel fraction. SA concentration of 1-2% with gamma ray irradiation
dose of 30 kGy was a suitable condition to produce a good hydrogel with
properties as follow, gel fraction of 75.83%-78.70%, swelling ratio of
69.12-80.14 g/g, and maximum water evaporated of 54.21-76.41%, the pH value
ranged 5.60-5.65. The hydrogels produced are suitable to be used for wound dressing, especially for wet wounds,
and can be applied for two days.
Keywords: Sodium alginate,
polyvinyl alcohol, gamma ray irradiation, hydrogel, wound dressing
Author: Thamrin Wikanta,
Erizal
Journal Code: jpperikanangg130024
