Clinically Relevant Optimization Based on Simulated Annealing Algorithm in IMRT for Prostate Cancer

Abstract: Given the advantage and trend of the clinically relevant optimization in radiotherapy, a novel optimization method using objective function based on tumor control probability (TCP) and normal tissue complication probability (NTCP) was proposed, which can improve global optimization capacity of simulated annealing optimization algorithm (SA) by increasing poor solutions acceptance rate. Theeffectiveness and superiority of the new method was verified in prostate cancer cases. Experimentalresults show that the proposed radiotherapy optimization method, not only can improve DVH curve of organs at risk, reduce the NTCP, and improve the therapeutic gain ration, but also can decrease hot spotsand gain better dose distribution uniformity of the target.
Keywords: Simulated annealing; Tumor control probability; Nature tissue control probability
Author: Caiping Guo, Linhua Zhang
Journal Code: jptkomputergg160116

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