Design of Indicator Strip Using Polystyrene (PS) and Polymethylmethacrylate (PMMA) for Detection of Diclofenac Sodium in Traditional Pain Relief Herbal Medicines

ABSTRACT: Diclofenac sodium is one of analgesic which is often added to traditional pain relief herbal medicines to enhance the effects. One of qualititative method that is easy, efficient and simple testing is an indicator strip. Indicator strip based Polystyrene (PS) and Polymethylmethacrylate (PMMA) was made for the examination of diclofenac sodium that were misused as a drug chemical compound in traditional pain relief herbal medicine. Strip indikator was made by reagent blending method with specific reagents used, namely, copper sulphate (CuSO4), ferric chloride (FeCl3) and vanillin sulphate. The working principle of the indicator strip in detecting the presence of diclofenac sodium in herbal medicine is with the occurrence of a color reaction. The concentration of PS and PMMA was made in a variation of 5%, 7.5% and 10%, and the mixture of PS: PMMA 1: 5 and 1: 6 concecutively with a ratio of solvent: reactant 6: 4; 7: 3 and 8:2. The test results showed that the best indicator strip is PMMA-CuSO4 5% (7: 3), PMMA-FeCl3 5% (7: 3) and PMMA-Vanillin sulphate 7.5% (7: 3). The detection limit and stability of the strip indicators PMMA-CuSO4 5% (7: 3) are at 50 ppm and is stable up to 29 weeks, PMMA-FeCl3 5% (7: 3) has a detection limit 12,500 ppm and is stable up to 29 weeks, and PMMA-vanillin sulphate 7,5% (7: 3) has a detection limit 500 ppm and is stable up to 29 weeks. The results showed that the indicator strip can be used as an alternative method to detect diclofenac sodium in herbal medicine and finally controlling addition of chemicals in to herbal medicine.
KEYWORDS: Diclofenac Sodium; PS; PMMA; Indicator Strip
Author: Ibrahim Dalli, Danni Ramdhani, Aliya Nur Hasanah
Journal Code: jpkimiagg170023

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