Uji Toksisitas Ekstrak Etanol Daun Tanaman Tembakau (Nicotiana tabacum L.)
Abstract: Tobacco (Nicotiana
tabacum L.) was a popular plant, usually used as cigarette material,
traditional medicine, chewy tobacco and natural insecticide. This study aims to
investigate toxicity effects of tobacco to mice (Mus musculus). The study had
been done from March to July 2015 in Plant Physiology Laboratory of Mathematic
and Natural Sciences Unimed and Phatology Laboratory USU. The study used male
mice as the animal test. Twenty-five mices were divided in to 5 groups. One
control group and four groups were given the ethanolic extracts of tobacco in
four doses 10%; 15%; 20%; dan 25% orally. Evaluation of toxic effects was 24
hours until 3 days after administration. Evaluation included physical and physiological
adverse, behaviour changes, and histopathologycal adverse of liver and kidney.
According to the results of study, ethanolic extract of tobacco made a systemic
toxicity. Most of doses (except control) caused acute toxicity symptoms and
immediately death to the tested animals. It affected mices in physic, behaviour
and anatomy. The toxic symptoms were uncontrolable movement, aggressivity, tail
abnormality, coordination damages, pupil extention, and refflects damages.
Another effects were gastric, intestinal and testis inflammations. The liver
and kidney were highly susceptible to toxicant. Histopathologycal examination
showed that toxic affected congestion and necrosis in liver and kidney.
Penulis: Puji Prastowo, Selvia
Dewi Pohan, Khairiza Lubis
Kode Jurnal: jpbiologidd160365
