STUDI POTENSI EKSTRAK BRUCEA JAVANICA SEBAGAI BIOAKTIF ANTIKANKER PAYUDARA TERHADAP SEL T47D
Abstract: This research would
bioassay the anticancer activity ofBrucea javanica extract toward T47D breast
cancercell by in-vitro method, using SRB dyed. In order to study the mechanism,
a dot blotting method was carried out to observe the interaction between the
Brucea javanica extract with the chromosomal DNA molecule of T47D Cell Line.
The interaction results were analyzed with High Performance Liquid
Chromatography (HPLC) methods. The result of anticancer activity assay toward
T47D cell showed that Brucea javanica extract has activity with IC50 2.69 g/mL,
whereas, the interaction result was analyzed with High Performance Liquid
Chromatography (HPLC) methods, exhibited the reduction peaks with the retention
time 2.26; 3.63 and 3.94 minutes. It was concluded that the bioactive activity
ofBrucea javanica due to the presenceof these candidates.
Penulis: Rina Andriyani,
Zalinar Udin
Kode Jurnal: jpkimiadd100237
