Seduhan Jahe Menurunkan Ekspresi TNF α pada Tikus Putih yang Diberi Diet Tinggi Lemak (HFD)
Abstract: Cardiovascular
disease still one of the highest death factor in Indonesia. Ginger as an anti-atherosclerosis
could be one of the alternatives that are being developed to decrease the
cardiovascular disease. The general aims of this research were determining the
mechanism of ginger as anti-atherosclerosis to decrease the risk of
cardiovascular disease.Research design used was “The Randomized Posttest only
Control Group Design”. By this research, the experimental unit was Rattus
norvegicus, male; in the age of 3 months and total number were thirty.
Independent variable of this research was
steeping of ginger, the dose various of steeping ginger
(A.control, B. HFD, CHFD+4gZO, 3g + bay leaf, and 5g), and dependent
variable was Tumor Necrotic Factor
(TNF)α of tissue lipid. TNF α expression was measured by using ELISA
method. The data was analyzed by using
ANOVA.Based on the analysis, it showed that steeping of ginger was decreased
the expression of TNF-α in fat tissue (Control 56,30 113,17 pg/mL, HFD + Exercise 94,30, HFD + Ginger 4
g, HFD + Ginger 6 g 74,33 pg/mL, 3g +
bay leaf = 493 pg /mL). Steeping of ginger decreased the risk of TNF α
expression that as factor cause of atherosclerosis.
Penulis: Nurul Mahmudati
Kode Jurnal: jpbiologidd160186
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