Pengaruh Kitosan Terhadap Kadar Residu Pb Ginjal Tikus Putih (Rattus Sp.) Jantan Yang Dipapari Plumbum Asetat
Abstract: The study aimed to determine the effect of
chitosan on the kidney of rats (Rattus
sp.) exposed to lead acetate. Thirty five male animals weighing 250g were
divided into 7 groups: K group as a
control (without treatment), P1
received Pb (40 mg/kg bw as lead
acetate), while P2, P3, and P4, all
received Pb (40 mg/kg bw) and chitosan (0,5%, 0,75%, and 1% respectively). P5
group received only chitosan (1%) and P6 group received acetic acid. After 7
weeks of treatment, the animals were
sacrificed and the kidneys were isolated. Kidney damage was observed with
residue of Pb in kidney tissue was evaluated using Atomic Absorption
Spectrophotography. Chitosan able to decrease kidney damage resulted from Pb treatment. Residue of Pb in the kidney of rat exposed to Pb acetate was
decreased after chitosan treatment. In conclusion, chitosan has the ability to
reduce residue of Pb after exposed Pb. The effectiveness of chitosan as a
chelating agent for Pb in the organs is important for
further investigated.
Penulis: Ulina Catarina Jeni
Simatupang
Kode Jurnal: jpbiologidd160489
