ANTICANCER ACTIVITY OF ETHANOLIC EXTRACT OF Selaginella plana HIERON. ON T47D CELL LINE IN VITRO
Abstract: Selaginella sp
belongs to the Selaginellaceae family. It has been used in China and Indonesia
as a traditional medicine. It has several medicinal properties including
antibacterial, anticardiovascular, and anticancer agent. The aim of the present
study was to access the anticancer property of the ethanolic extracts of Selaginella plana Hieron. on T47D
breast cancer cell line. The proliferation of T47D cell line was detected by
SRB (Sulforhodamine B) assay which was measured at a wavelength of 515 nM. The
result showed that the IC50 of the ethanolic extract was determined at 7.03
pg/mL. This significant activity was assumed due to its high total flavonoid
content. The totalflavonoid content of the ethanolic extract was 23.04%. Flow
cytometry analysis indicated that the extract may undergo the cell death via
apoptosis pathway. In conclusion, the ethanolic extract of Selaginella plana
Hieron: has considerable activity in inhibiting T47D cell line proliferation.
Penulis: Chandra Risdian, Sri
Handayani, Zalinar Udin, Rina Andriyani, Marissa Angelina
Kode Jurnal: jpkimiadd110187
