AKTIVITAS ANTIJAMUR EKSTRAK TERIPANG DARAH (HOLOTHURIA ATRA JEAGER.) TERHADAP PERTUMBUHAN JAMUR MALASSEZIA FURFUR PENYEBAB PANU
ABSTRACT: Holothuria atra is
marine creature which is potential as a source of antifungal material.This
research aims to find out the antifungal activities of the extract of H. atra
against the Malassezia furfur fungus that causes tinea versicolor. The extract
of H. atra was obtained through a maceration method using methanol. The
antifungal activities were tested using Kirby-Bauer disc paper diffusion method
on the Saboraud Dextrose Agar (SDA) medium enriched with olive oil. The
research used the extract with concentrations of 20%, 40%, 60%, 80%, and 100%
with 2% of ketoconazole positive control and DMSO (Dimethyl Sulfoxid) negative
control. The secondary metabolite test indicated content of alkaloids,
triterpenoids, and saponins in the extract. The test results of antifungal
activities showed that alllevels of concentration could inhibit the growth of
M. furfur fungus characterized by the formation of a clear zone around the
paper disc. The extract of H. atra is fungistatic with a very strong inhibition
category. The concentration of 20% is the most effective in inhibiting the M.
furfur fungus with a clear zone diameter of 22,16mm.
Penulis: Tuti Alawiyah, Siti
Khotimah, Achmad Mulyadi
Kode Jurnal: jpbiologidd160117
