PHYSICAL CHARACTERIZATION OF IBUPROFEN-STEARIC ACID BINARY MIXTURE DUE TO COMPRESSION FORCE
Abstract: Aim of this research
is to determine physical characteristic of ibuprofen-stearic acid due to
compression force. Binary mixture of ibuprofen-stearic acid with weight ratio
of 4:6, 5:5, and 6:4 was compressed under various compression force using
hydraulic press with 13mm diameter flat punch.Identification of solid state
interaction between these two components was performed by Hot Stage Microscopy
(HSM). Physical characterization has been studied byDifferential Thermal
Analysis (DTA), X-ray Powder Diffraction (XRPD), Scanning Electron Microscopy
(SEM), and (Fourier Transform Infrared (FT-IR) spectroscopy. According to
hardness measurement, 4:6 weight ratio has the highest tensile strength on
170.6N/cm2 under 19.93kN compression force. Interaction identification by HSM
showed single blank line that indicates eutectic formation. Thermal analysis of
DTA also revealed eutectic formation upon compression whichthe endotermic peak
of ratio of 4:6has the lowest melting temperature of 53.2°C. X-ray diffraction
of three peaksgenerally showed that peak intensity decreases as compression
force increases, but at particular point it begins to increase again. Sintering
phenomenon at the surface of compressed tablet was observed from SEM analysis.
FT-IR study confirms the formation of simple eutectic.
Author: Dwi Setyawan, Dewi
Isadiartuti, Sita Desti Betari, Diajeng Putri Paramita
Journal Code: jpfarmasigg160021
