PENGARUH WAKTU PROTEKSI INFUSA BIJI Persea americana Mill. TERHADAP HEPAR DAN GINJAL TIKUS TERINDUKSI KARBONTETRAKLORIDA
Abstract: The aim of this
research is to investigate the protective activity of the infusion of seed of
Persea americana Mill. (IBPA) against carbon tetrachloride-induced
hepatotoxicity and nephrotoxicity in rats. Healthy rats were weighed and
randomly divided into 6 groups of 5 animals in each. Group 1 were treated with
olive oil (2ml/kg, i.p) as negative control. Group 2 received carbon
tetrachloride (2 ml/kg, i.p.). Group 3 received IBPA 360.7 mg/kg once daily for
6 hours (control of dose IBPA). Group 4-6 received IBPA at doses 360.7 mg/kg
orally once for 1, 4 and 6 hours respectively received treated carbon
tetrachloride. Blood sample from all groups was obtained by sinus orbitalis for
the estimation serum transaminase and creatinine. The pretreatment 1,4 and 6
hours of infusion of seed of Persea americana Mill. has a potent protective
activity upon carbon tetrachloride-induced hepatic and nephron damage in rats.
Penulis: Lydia Setiawan,
Inneke Devi Permatasari, Phebe Hendra
Kode Jurnal: jpfarmasidd140401
