Pengaruh Polivinilpirolidon K-30 terhadap Disolusi Ketoprofen dalam Sistem Dispersi Padat
Abstract: Effects of
polyvinylpyrrolidone K-30 on dissolution characteristics of solid dispersion
systems have been studied. Solid dispersions were prepared by solvent method
using several ratios of ketoprofen-polyvinylpyrrolidone K-30 as follows 1:9,
3:7, 5:5, 7:3, 9:1. Physical mixtures of ketoprofen-polyvinylpyrrolidone K-30
were used as a comparison. The solid dispersion systems and physical mixtures
were evaluated for physicochemical properties and dissolution characteristics.
Dissolution tests were measure with modified basket method using pH 7.2
phosphate buffer as dissolution medium. Samples were taken up after 5, 10, 15,
20, 30, 45, and 60 minutes. Results generally showed that solid dispersion
system of ketoprofenpolyvinylpyrrolidone K-30 have a different physicochemical
properties compared to physical mixtures and pure ketoprofen and exhibited
better dissolution rate and dissolution efficiency of ketoprofen. Dissolution
efficiency and dissolution rate constant of the solid dispersion system were
59.41%, and 1.66 mg/s, respectively.
Penulis: Rieke Azhar, Muslim
Suardi, Salman Umar
Kode Jurnal: jpfarmasidd090057
