Pengaruh Pemberian Kitosan Cangkang Udang Putih (Penaeus merguiensis) terhadap Ketebalan Trabekular Femur Tikus Wistar Betina Pasca Ovariektomi
Abstract: There are low bone
density and defects in bone micro-architecture which led to a significant
increases of bone fragility and bone fracture in osteophorosis, due to an
oestrogen deficiency in post-menopause woman. Natural polymer which has
potential action on bone remodelling is chitosan. Chitosan can reduce the
production of IL-1, IL-6, TNF-α and PGE2 osteoclast cell as well as increase
osteoblast cell differentiation in bone formation process. The study aimed to
determine the effect of chitosan white shrimp shell on the trabecular thickness
of femur female wistar rats post-ovariectomy. This research was the quasy
experimental laboratory research using female wistar rats that were divided
into three groups; a non-ovariectomy as control, a negative ovariectomy, and an
ovariectomy treatment group that was given chitosan 0,05 g/day. After 14 days,
the experimental mice were euthanized and trabecular thickness was measured.
There were 59,53µm, 32,44µm and 78,43µm trabecular thickness in the control
group, the negative control group and the treatment group, respectively. The
data were analysed using one way ANOVA and they showed a significant
differences between all groups (p=0,000). It can be concluded that the chitosan
of white shrimp shell can significantly increase trabecular thickness femur female
wistar rats post-ovariectomy.
Penulis: Suci Rizalah I,
Muhammad Hasan, Septa Surya Wahyudi
Kode Jurnal: jpkesmasdd160104
