FORMULASI MATRIKS TRANSDERMAL PENTAGAMAVUNON-0 DENGAN KOMBINASI POLIMER PVP K30 DAN HIDROKSIPROPIL METILSELULOSA
Abstract: Transdermal delivery
system is one of the delivery system for Pentagamavunon-0 (PGV-0) to avoid the
high intensity of first pass metabolism of PGV-0 in peroral route. The purpose
of this research was to optimize the formula of PGV-0 transdermal matrix with a
combination of PVP K30 and HPMC polymers.The simplex lattice optimization
approach of the transdermal matrix formulas was performed by using Design
Expert 7.1.5 software. The visual appearance, weight, thickness, moisture
content, moisture uptake, folding endurance, drug content, and dissolution
efficiency of the release profil of PGV-0 from the matrix for 6 hours were
evaluated as responses to determine optimum formula of matrix. The result
showed that a combination of PVP K30 and HPMC polymers had a significant
influence on the visual appearance, moisture content, and dissolution
efficiency of PGV-0. Combination of 1.98% of PVP K30 and 4.52% of HPMC as the
optimum formula could produce homogeneous and flexible matrix with moisture
content of 3.21%. The dissolution efficiency was 9.11%, indicating that 101.93
µg of PGV-0 was released from the optimum formula during 6 hours.
Penulis: Beti Pudyastuti,
Akhmad Kharis Nugroho, Sudibyo Martono
Kode Jurnal: jpfarmasidd140421
