EFEKTIVITAS ANTIDIABETES EKSTRAK DAUN RAMBUSA (Passiflora foetida L.) PADA MENCIT (Mus musculus) DENGAN INDUKSI GLUKOSA
Abstract: Passiflora foetida
leaves used by the society for generations as a natural antidiabetic drug
research aims to test the effectiveness of the leaf extract of Passiflora foetida
with variations of a dose of 250 mg / kg, 500 mg / kg, and 750 mg / kg in
lowering blood sugar levels in mice. Passiflora foetida leaves were extracted
by sokhletasi method with 70% ethanol, the extract was tested on 15 mice, the
test animals were randomized into 5 groups consist of negative control group
given 0.5% Na-CMC, positive control group was given glibenclamide 0, 65 mg /
kg, and the treatment group were given the leaf extract of Passiflorafoetida
with variations of each dose of 250 mg / kg, 500 mg / kg, 750 mg / kg. To
increase blood sugar levels in mice induced glucose 50%. Measurement of blood
sugar levels in mice were performed using an easy touch glucometer and blood is
taken via the lateral tail vein. The results showed that the percentage of
blood sugar levels drop to a negative control is 13.1%, for a dose of 250 mg /
kg body weight of 29.52%, for a dose of 500 mg / kg was 38.79%, to dosis750 mg
/ kg was 49, 21%, and 48.1% for the positive control. The results showed that
the leaf extract of Passiflorafoetida at a dose of 750 mg / kg is most
effective as an antidiabetic
Penulis: Khildah Khaerati,
Ihwan, Musdalifah S Maya
Kode Jurnal: jpfarmasidd150308
